Tuesday, 31 March 2015

EPINEPHRINE & NOREPINEOHRINE



Major action is on cardiovascular system.
 epinephrine strengthens the contractility of the mayocardium & increases its rate of contraction.

   Action of epinephrine on respiratory              system .
> Epinephrine causes powerful bronchodilation by acting directly on bronchial smooth muscle.
> Epinephrine also inhibits the release of allergy mediators such as histamines from mast cells..


And its another action cause
  
                   Hyperglycemia
                       Lipolysis

Actions of norepinephrine

 Vaso constriction > norepinephrine  cause a rise in peripheral resistance due to intense vasoconstriction of most vascular beds, including the kidney.
 Norepinephrine causes greater vasoconstriction than epinephrine .


Baroreceptor reflex
 
    In isolated cardiac tissue , noepinephrine stimulates cardiac contactility.

 Effect of atropine pretreatment
 It blocks the transmission of vagal effects , is given before noepinephrine,  stinulation of the heart by noepinephrine is evident as tachycardia. 

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